Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128260 | 0.88 | ALDH1A1 (0.48) | HCAR2CYP4F2CYP4A11ALDH1A1LMNA | |
| SCHEMBL128565 | 0.83 | CYP4F2 (0.42) | HCAR2CYP4F2CYP4A11ALDH1A1LMNA | |
| SCHEMBL129290 | 0.82 | CYP4F2 (0.52) | CYP4F2CYP4A11ALDH1A1LMNATSHR | |
| SCHEMBL1105061 | 0.82 | HCAR2 (0.39) | HCAR2CYP4F2CYP4A11ALDH1A1LMNA | |
| SCHEMBL8849916 | 0.80 | CYP4F2 (0.46) | HCAR2CYP4F2CYP4A11ALDH1A1LMNA | |
| SCHEMBL1164887 | 0.80 | CYP4F2 (0.41) | HCAR2CYP4F2CYP4A11ALDH1A1LMNA | |
| SCHEMBL7039335 | 0.78 | CYP4F2 (0.40) | HCAR2CYP4F2CYP4A11ALDH1A1LMNA | |
| SCHEMBL18856225 | 0.78 | HCAR2 (0.36) | HCAR2CYP4F2CYP4A11ALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL27957647 | 0.78 | CYP4F2 (0.44) | HCAR2CYP4F2CYP4A11ALDH1A1LMNA | |
| SCHEMBL7105771 | 0.77 | HCAR2 (0.39) | HCAR2ALDH1A1LMNATSHRESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450319-B2 | Pyrrolopyridazinone compound | UBE INDUSTRIES, LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| EP-1982986-B1 | PYRROLOPYRIDAZINONE COMPOUND AS PDE4 INHIBITOR | UBE INDUSTRIES (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20090036453-A1 | Pyrrolopyridazinone Compound | UBE INDUSTRIES, LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1982986-A1 | PYRROLOPYRIDAZINONE COMPOUND | Ube Industries, Ltd. (JP) | 2008-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036453-A1 | Pyrrolopyridazinone Compound | CBR3, CBR1, CYC1 | HCAR2 99/4885CYP4F2 105/4885CYP4A11 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.