Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11893762 | 0.81 | MAPT (0.51) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL11893761 | 0.81 | MAPT (0.51) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL2793954 | 0.76 | SMN1; SMN2 (0.51) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL21315673 | 0.75 | MAPT (0.53) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL29961819 | 0.75 | MAPT (0.53) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL16407597 | 0.75 | MAPT (0.64) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL21315684 | 0.74 | MAPT (0.54) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL29961789 | 0.74 | MAPT (0.54) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL21315660 | 0.73 | MAPT (0.52) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 | |
| SCHEMBL4305240 | 0.73 | SMN1; SMN2 (0.58) | ALDH1A1MAPTHPGDAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694482-A1 | WNT PATHWAY ANTAGONISTS | Siena Biotech S.p.A. (IT) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012136492-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2012-10-11 | — | — | WO | disclosed |