Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12987717 | 0.98 | KDM4E (0.41) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL12987105 | 0.85 | PDE5A (0.39) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL12987735 | 0.81 | KDM4E (0.40) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL12987270 | 0.78 | MEN1 (0.40) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL12987397 | 0.77 | KDM4E (0.51) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL12987706 | 0.72 | PDE4A (0.44) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL12987385 | 0.70 | TNKS2 (0.40) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL12987559 | 0.68 | ALDH1A1 (0.38) | ALDH1A1KDM4EHSD17B10HPGDLMNA | |
| SCHEMBL12987529 | 0.67 | ATM (0.35) | ALDH1A1HPGDBCHEACHESMN1; SMN2 | |
| SCHEMBL10287048 | 0.63 | CYP1A2 (0.46) | ALDH1A1KDM4EHSD17B10HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855214-B2 | Fused cyclic systems useful as inhibitors of TEC family protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-21 | — | — | US | disclosed |