Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 6/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130526 | 0.87 | CETP (0.39) | CETPPTGER1ARSLC1A5SLC6A9 | |
| SCHEMBL130971 | 0.83 | CETP (0.52) | CETP | |
| SCHEMBL1588216 | 0.79 | HTR2C (0.39) | CETPPTGER1SLC1A5HTR2CSLC6A4 | |
| SCHEMBL130203 | 0.79 | CETP (0.45) | CETPPTGER1PTPN1SLC1A5HTR2C | |
| SCHEMBL1587844 | 0.78 | SLC6A4 (0.43) | CETPPTGER1SLC1A5HTR2CSLC6A4 | |
| SCHEMBL1588309 | 0.78 | CETP (0.44) | CETPPTGDR2PTGER1 | |
| SCHEMBL132562 | 0.75 | CETP (0.40) | CETP | |
| SCHEMBL4510002 | 0.73 | NR3C1 (0.37) | CETP | |
| SCHEMBL129204 | 0.73 | CETP (0.39) | CETP | |
| SCHEMBL12062624 | 0.70 | CETP (0.57) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979331-B1 | TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-07 | — | — | EP | disclosed |