Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 10/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12991289 | 0.86 | PIK3CG (0.54) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL12992306 | 0.84 | ROCK2 (0.56) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL12992057 | 0.84 | PIK3CG (0.50) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL3842187 | 0.84 | PIK3CG (0.50) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL12991982 | 0.84 | XIAP (0.49) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL1886754 | 0.84 | PIK3CG (0.53) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL27656677 | 0.84 | PIK3CG (0.56) | PIK3CGPIK3CDPIK3CAPIK3CBXIAP | |
| SCHEMBL12991903 | 0.83 | PIK3CG (0.67) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL1890819 | 0.82 | PPID (0.55) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL12991242 | 0.82 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010144513-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-16 | — | — | WO | disclosed |