Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 3/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | LIG1 | P18858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198612 | 0.78 | MAPT (0.53) | CHRNA4KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL700764 | 0.77 | APEX1 (0.55) | APEX1KMT2AKDM4EPTGER4DAO | |
| SCHEMBL274316 | 0.77 | CHRNA4 (0.49) | APEX1CHRNA4KMT2AKDM4EMCL1 | |
| SCHEMBL14620144 | 0.76 | APEX1 (0.53) | APEX1KMT2AKDM4EPTGER4DAO | |
| SCHEMBL20582083 | 0.74 | KMT2A (0.48) | APEX1KMT2AKDM4EMCL1PIM1 | |
| SCHEMBL29952181 | 0.74 | APEX1 (0.52) | APEX1KMT2AKDM4EPIM1PTGER4 | |
| SCHEMBL28651161 | 0.74 | DAO (0.63) | APEX1KMT2AKDM4EMCL1PIM1 | |
| SCHEMBL27770730 | 0.74 | POLB (0.56) | APEX1KMT2AKDM4EMCL1PIM1 | |
| SCHEMBL9311435 | 0.72 | KDM4E (0.52) | APEX1KMT2AKDM4EPTGER4DAO | |
| SCHEMBL22638673 | 0.72 | APEX1 (0.46) | APEX1KMT2AKDM4EMCL1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264017-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-12-22 | — | — | EP | disclosed |