Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 3/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 3/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 3/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12449697 | 1.00 | ACHE (0.43) | ACHEKDM4ELMNARAB9AGBA1 | |
| SCHEMBL12449706 | 1.00 | ACHE (0.43) | ACHEKDM4ELMNARAB9AGBA1 | |
| SCHEMBL12449648 | 0.90 | KDM4E (0.41) | ACHEKDM4ELMNAPIK3CDPIK3R2 | |
| SCHEMBL12765 | 0.90 | KDM4E (0.41) | ACHEKDM4ELMNAPIK3CDPIK3R2 | |
| SCHEMBL8261146 | 0.89 | ACHE (0.55) | ACHEGBA1HTR4HSD11B1NAMPT | |
| SCHEMBL18390909 | 0.89 | ACHE (0.50) | ACHEKDM4ELMNARAB9AGBA1 | |
| SCHEMBL27274600 | 0.87 | GBA1 (0.44) | ACHEKDM4ELMNARAB9AGBA1 | |
| SCHEMBL12827 | 0.79 | ACHE (0.43) | ACHEKDM4ELMNARAB9AGBA1 | |
| SCHEMBL25854024 | 0.79 | ACHE (0.43) | ACHEKDM4ELMNARAB9AGBA1 | |
| SCHEMBL12449646 | 0.79 | ACHE (0.43) | ACHEKDM4ELMNARAB9AGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |