Sugi Predict

Sugi Predict / Compounds / SCHEMBL1299990

SCHEMBL1299990

SCHEMBL1299990

CC(C)(C)OC(=O)N1C(=O)C(c2ccc(Cl)c(F)c2)CC1(C)C

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 1/20 0.38
▸ CRBN Q96SW2 1/20 0.38
▸ TACR3 P29371 1/20 0.38
▸ HRH3 Q9Y5N1 4/20 0.37
▸ PDE4A P27815 1/20 0.36
▸ PDE4B Q07343 1/20 0.36
▸ PDE4C Q08493 1/20 0.36
▸ PDE4D Q08499 1/20 0.36
▸ SLC6A2 P23975 2/20 0.36
▸ SLC6A4 P31645 2/20 0.36
▸ SLC6A3 Q01959 1/20 0.36
▸ F13A1 P00488 1/20 0.34
▸ TGM2 P21980 1/20 0.34
▸ TGM1 P22735 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ MDM2 Q00987 1/20 0.34
▸ RORC P51449 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1300070 0.85 SLC6A2 (0.39) SLC6A2SLC6A4SLC6A3CYP3A4MDM2
SCHEMBL190946 0.83 MEN1 (0.44) DDB1CRBNMDM2RORCMEN1
SCHEMBL680915 0.78 RORC (0.44) RORCKMT2A
SCHEMBL2577978 0.73 MEN1 (0.41) DDB1CRBNPDE4APDE4BPDE4C
SCHEMBL12497537 0.73 MEN1 (0.46) TACR3HRH3PDE4APDE4BPDE4C
SCHEMBL28196950 0.73 MEN1 (0.46) TACR3HRH3PDE4APDE4BPDE4C
SCHEMBL29640273 0.72 BRD4 (0.41) TACR3SLC6A2SLC6A4
SCHEMBL20908110 0.72 BRD4 (0.41) TACR3SLC6A2SLC6A4
SCHEMBL28889760 0.72 BRD4 (0.41) TACR3SLC6A2SLC6A4
SCHEMBL4886160 0.72 TACR3 (0.51) DDB1CRBNTACR3HRH3PDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150191479-A1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2015-07-09 — — US disclosed
US-20130065908-A1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2013-03-14 — — US disclosed
US-8329701-B2 Dihydrofuro pyrimidines as AKT protein kinase inhibitors ARRAY BIOPHARMA INC. (US) 2012-12-11 — — US disclosed
US-20110269773-A1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2011-11-03 — — US disclosed
EP-2049546-B1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2010-12-29 — — EP disclosed
EP-2049546-A1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS Array Biopharma, Inc. (US) 2009-04-22 — — EP disclosed
WO-2008006025-A1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2008-01-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130065908-A1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS DPYD, DTYMK, PIK3CA DDB1 356/4885CRBN 3862/4885TACR3 4108/4885
US-20110269773-A1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS DPYD, PIK3CA, DTYMK DDB1 349/4885CRBN 4043/4885TACR3 4065/4885
US-20150191479-A1 DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS DPYD, DTYMK, PIK3CA DDB1 356/4885CRBN 3862/4885TACR3 4108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.