Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.38 |
| ▸ | GIPR | P48546 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667855 | 0.84 | GCGR (0.54) | GCGRHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL9071543 | 0.83 | GCGR (0.59) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667854 | 0.82 | GCGR (0.54) | GCGRHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2667315 | 0.76 | GCGR (0.41) | GCGRHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL2667469 | 0.70 | GCGR (0.56) | GCGRHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL9071629 | 0.69 | GCGR (0.61) | GCGRHDAC1GIPR | |
| SCHEMBL13003176 | 0.65 | GCGR (0.56) | GCGRGIPR | |
| SCHEMBL13003086 | 0.65 | GCGR (0.43) | GCGRHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2667886 | 0.65 | GCGR (0.81) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL9071635 | 0.65 | GCGR (0.75) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590336-B1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2010-12-01 | — | — | EP | disclosed |