Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 18/20 | 0.53 |
| ▸ | GIPR | P48546 | 6/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | USP5 | P45974 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667291 | 0.95 | GCGR (0.59) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667300 | 0.87 | GCGR (0.58) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL12360426 | 0.86 | GCGR (0.59) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL13749330 | 0.84 | GCGR (0.44) | GCGRGIPRCYP2C9USP5 | |
| SCHEMBL2667902 | 0.83 | GCGR (0.63) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2255802 | 0.83 | MEN1 (0.48) | GCGRGIPRUSP5 | |
| SCHEMBL2667903 | 0.82 | GCGR (0.61) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2251590 | 0.81 | KMT2A (0.48) | GCGRGIPRCYP2C9 | |
| SCHEMBL2667349 | 0.80 | GCGR (0.59) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667352 | 0.80 | GCGR (0.53) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590336-B1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2010-12-01 | — | — | EP | disclosed |