Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 19/20 | 0.55 |
| ▸ | GIPR | P48546 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9071600 | 0.91 | GCGR (0.67) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL13003187 | 0.85 | GCGR (0.49) | GCGRGIPR | |
| SCHEMBL2249887 | 0.81 | GCGR (0.82) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2255081 | 0.78 | GCGR (0.68) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL13003080 | 0.78 | GCGR (0.48) | GCGRGIPR | |
| SCHEMBL2667307 | 0.75 | GCGR (0.85) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL13003258 | 0.72 | GCGR (0.87) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2253924 | 0.71 | GCGR (1.00) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667402 | 0.71 | GCGR (0.60) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2247572 | 0.68 | GCGR (0.79) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590336-B1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2010-12-01 | — | — | EP | disclosed |