Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060854 | 0.85 | NPC1 (0.46) | NPC1RAB9APOLBSMN1; SMN2TDP1 | |
| SCHEMBL13006174 | 0.83 | ERN1 (0.53) | ERN1SMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL13005468 | 0.82 | NPC1 (0.43) | NPC1RAB9APOLBSMN1; SMN2TDP1 | |
| SCHEMBL13006165 | 0.82 | CYP1A2 (0.45) | NPC1RAB9APOLBSMN1; SMN2TDP1 | |
| SCHEMBL13006167 | 0.78 | NPC1 (0.39) | NPC1RAB9APOLBSMN1; SMN2TDP1 | |
| SCHEMBL2108698 | 0.76 | SLC2A1 (0.53) | NPC1RAB9APOLBSMN1; SMN2LPAR1 | |
| SCHEMBL31482105 | 0.74 | KMT2A (0.51) | SMN1; SMN2TDP1ALDH1A1MAPTHTT | |
| SCHEMBL26163562 | 0.73 | TDP1 (0.52) | ERN1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL696160 | 0.73 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL13006159 | 0.72 | NPC1 (0.53) | NPC1RAB9APOLBSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |