Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14275789 | 0.87 | AXL (0.56) | AXLFLT3MAPTALDH1A1MAPK1 | |
| SCHEMBL14275788 | 0.85 | AXL (0.54) | AXLFLT3MAPTALDH1A1SYK | |
| SCHEMBL14275790 | 0.84 | AXL (0.53) | AXLFLT3MAPTALDH1A1BACE1 | |
| SCHEMBL14275800 | 0.84 | AXL (0.53) | AXLFLT3MAPTALDH1A1BACE1 | |
| SCHEMBL3956556 | 0.84 | AXL (0.63) | AXLFLT3MAPTALDH1A1MAPK1 | |
| SCHEMBL14275791 | 0.83 | AXL (0.52) | AXLFLT3MAPTALDH1A1BACE1 | |
| SCHEMBL13006574 | 0.83 | AXL (0.52) | AXLFLT3MAPTALDH1A1SYK | |
| SCHEMBL14275793 | 0.83 | AXL (0.52) | AXLFLT3MAPTALDH1A1SYK | |
| SCHEMBL14275797 | 0.83 | AXL (0.52) | AXLFLT3MAPTALDH1A1BACE1 | |
| SCHEMBL14275802 | 0.82 | BACE1 (0.53) | AXLFLT3ALDH1A1SYKBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791830-B1 | DIAMINOTRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2010-12-29 | — | — | EP | disclosed |
| US-7329652-B2 | Diaminotriazole compounds useful as protein kinase inhibitors | VERTEX PHARAMACEUTICALS INCORPORATED (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329652-B2 | Diaminotriazole compounds useful as protein kinase inhibitors | VERTEX PHARAMACEUTICALS INCORPORATED (US) | 2008-02-12 | — | — | US | disclosed |