Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.47 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2406519 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL4385726 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2404044 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL25015819 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2405787 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL24920262 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2405113 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL25015820 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2406734 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2405816 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740578-B1 | 4- 2- (CYCLOALKYLAMINO) PYRIMIDIN-4-YL ] - (PHENYL) - IMIDAZOLIN-2- ONE DERIVATIVES AS P38 MAP- KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MITSUBISHI TANABE PHARMA CORP (JP) | 2010-12-15 | — | — | EP | disclosed |