Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.47 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007141 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2406519 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL4385726 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2404044 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL25015819 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2405787 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2405113 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL25015820 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2406734 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT | |
| SCHEMBL2405816 | 1.00 | CYP1A2 (0.48) | CYP1A2GNAI3GNAO1GNAI1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | PIK3CA, PIK3CG, PIK3CD | CYP1A2 3284/4885GNAI3 91/4885GNAO1 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.