Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.70 |
| ▸ | TOP1 | P11387 | 8/20 | 0.66 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.64 |
| ▸ | APLNR | P35414 | 1/20 | 0.64 |
| ▸ | CCR6 | P51684 | 1/20 | 0.64 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.61 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007183 | 0.98 | PTPN1 (0.68) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL12945048 | 0.94 | TOP1 (0.64) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL15393753 | 0.94 | TOP1 (0.62) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL12944982 | 0.93 | CXCR5 (0.67) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL19360128 | 0.93 | CXCR5 (0.67) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL4278231 | 0.93 | PTPN1 (0.68) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL29934956 | 0.93 | PTPN1 (0.68) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL30079641 | 0.93 | PTPN1 (0.68) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL23584144 | 0.93 | CXCR5 (0.61) | PTPN1TOP1CXCR5APLNRCCR6 | |
| SCHEMBL19978662 | 0.92 | CXCR5 (0.60) | PTPN1TOP1CXCR5APLNRCCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190256543-A1 | METHODS AND COMPOUNDS FOR MODULATING THE SECRETION OR EXPRESSION OF ADHESION PROTEINS OR ANGIOPOIETINS OF CELLS | PACIFIC ARROW LTD (CN) | 2019-08-22 | — | — | US | disclosed |
| US-20160354397-A1 | METHODS AND COMPOUNDS FOR MODULATING THE SECRETION OR EXPRESSION OF ADHESION PROTEINS OR ANGIOPOIETINS OF CELLS | PACIFIC ARROW LTD (CN) | 2016-12-08 | — | — | US | disclosed |
| US-9382285-B2 | Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells | PACIFIC ARROW LIMITED (CN) | 2016-07-05 | — | — | US | disclosed |
| US-8586719-B2 | Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents | PACIFIC ARROW LIMITED (CN) | 2013-11-19 | — | — | US | disclosed |
| US-20100317606-A1 | NOVEL TRITERPENES FOR MODULATING GENE EXPRESSION AND CELL MEMBRANE, AND AS ANTIPROTOZOAL AGENTS | PACIFIC ARROW LIMITED (CN) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190256543-A1 | METHODS AND COMPOUNDS FOR MODULATING THE SECRETION OR EXPRESSION OF ADHESION PROTEINS OR ANGIOPOIETINS OF CELLS | TEK, FN1, MYL6 | PTPN1 1136/4885TOP1 2449/4885CXCR5 1259/4885 |
| US-20100317606-A1 | NOVEL TRITERPENES FOR MODULATING GENE EXPRESSION AND CELL MEMBRANE, AND AS ANTIPROTOZOAL AGENTS | TEK, PTK2, MPL | PTPN1 1647/4885TOP1 1603/4885CXCR5 1487/4885 |
| US-20160354397-A1 | METHODS AND COMPOUNDS FOR MODULATING THE SECRETION OR EXPRESSION OF ADHESION PROTEINS OR ANGIOPOIETINS OF CELLS | TEK, FN1, MYL6 | PTPN1 1136/4885TOP1 2449/4885CXCR5 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.