Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6103100 | 0.80 | OPRK1 (0.54) | HTTOPRK1ALOX15TSHRLMNA | |
| SCHEMBL30721153 | 0.79 | OPRK1 (0.55) | HTTOPRK1MEN1KMT2AROCK2 | |
| SCHEMBL1516751 | 0.79 | OPRK1 (0.55) | HTTOPRK1MEN1KMT2AROCK2 | |
| SCHEMBL2213799 | 0.79 | OPRK1 (0.56) | HTTOPRK1ALOX15TSHRLMNA | |
| SCHEMBL27159916 | 0.76 | OPRK1 (0.48) | OPRK1MEN1KMT2ATSHRLMNA | |
| SCHEMBL31213058 | 0.76 | MEN1 (0.48) | HTTMEN1KMT2AROCK2ROCK1 | |
| SCHEMBL1516713 | 0.75 | OPRK1 (0.50) | HTTOPRK1ROCK2ROCK1 | |
| SCHEMBL6104069 | 0.74 | OPRK1 (0.58) | OPRK1 | |
| SCHEMBL3208403 | 0.73 | HTT (0.52) | HTTMEN1KMT2ATP53MAPT | |
| SCHEMBL3662266 | 0.72 | MEN1 (0.53) | HTTMEN1KMT2AALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264033-A1 | 3,5-DIPHENYL-SUBSTITUTED PYRROLO[2,3b]PYRIDINES USEFUL AS KINASE INHIBITORS | SGX Pharmaceuticals, Inc. (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2008124849-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |