Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | CTSV | O60911 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13011092 | 1.00 | CNR2 (0.98) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL13011091 | 1.00 | CNR2 (0.98) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL13011101 | 1.00 | CNR2 (0.98) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL13745671 | 0.99 | CNR2 (1.00) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL13746011 | 0.99 | CNR2 (1.00) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL178152 | 0.99 | CNR2 (1.00) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL13745625 | 0.99 | CNR2 (1.00) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL176600 | 0.99 | CNR2 (1.00) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL176719 | 0.99 | CNR2 (1.00) | CNR2MAPK1AURKACDK2MAPK10 | |
| SCHEMBL176651 | 0.99 | CNR2 (1.00) | CNR2MAPK1AURKACDK2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317633-A1 | HEXAHYDRO-CYCLOOCTYL PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | US | disclosed |
| US-7825151-B2 | Hexahydro-cyclooctyl pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-02 | — | — | US | disclosed |
| US-20080076814-A1 | Hexahydro-Cyclooctyl Pyrazole Cannabinoid Modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317633-A1 | HEXAHYDRO-CYCLOOCTYL PYRAZOLE CANNABINOID MODULATORS | CNR1, CNR2, FAAH | CNR2 2/4885MAPK1 1088/4885AURKA 4485/4885 |
| US-20080076814-A1 | Hexahydro-Cyclooctyl Pyrazole Cannabinoid Modulators | CNR1, CNR2, FAAH | CNR2 2/4885MAPK1 1088/4885AURKA 4485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.