Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 6/20 | 0.45 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433462 | 1.00 | BRD4 (0.45) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL3434768 | 0.81 | BRD4 (0.39) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL3434014 | 0.74 | BRD4 (0.45) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL3433034 | 0.73 | BRD4 (0.48) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL2725332 | 0.73 | BRD4 (0.60) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL9976375 | 0.73 | BRD4 (0.48) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL13012896 | 0.72 | BRD4 (0.39) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL3432096 | 0.72 | BRD4 (0.39) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL13012739 | 0.70 | BRD4 (0.46) | BRD4BRDTBRD2BRD3GAA | |
| SCHEMBL3435004 | 0.66 | BRD4 (0.48) | BRD4BRDTBRD2BRD3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |