Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433034 | 0.92 | BRD4 (0.48) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL2725332 | 0.86 | BRD4 (0.60) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL13012739 | 0.85 | BRD4 (0.46) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL3434014 | 0.83 | BRD4 (0.45) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL3434768 | 0.81 | BRD4 (0.39) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL13013567 | 0.80 | MAOB (0.44) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL13012896 | 0.79 | BRD4 (0.39) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL3432096 | 0.79 | BRD4 (0.39) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL13012731 | 0.77 | BRD4 (0.38) | BRD4BRDTBRD2BRD3KMT2A | |
| SCHEMBL3434370 | 0.76 | CACNA2D1 (0.40) | BRD4BRDTBRD2BRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629272-B2 | Tricyclic pyrimidine derivatives as wnt antagonists | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | WNT1, WNT3, WNT3A | BRD4 1105/4885BRDT 3239/4885BRD2 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.