Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 3/20 | 0.43 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1301460 | 1.00 | CDK8 (0.46) | CDK8GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL13152980 | 0.86 | MAP4K4 (0.44) | CDK8NPC1RAB9AABL1ALDH1A1 | |
| SCHEMBL3084233 | 0.86 | MAP4K4 (0.44) | CDK8NPC1RAB9AABL1ALDH1A1 | |
| SCHEMBL3084254 | 0.86 | MAP4K4 (0.44) | CDK8NPC1RAB9AABL1ALDH1A1 | |
| SCHEMBL1301605 | 0.77 | CDK8 (0.56) | CDK8GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1950804 | 0.77 | CDK8 (0.56) | CDK8GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3101977 | 0.77 | CDK8 (0.47) | CDK8GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1951208 | 0.76 | CDK8 (0.54) | CDK8GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1950004 | 0.76 | CDK8 (0.54) | CDK8GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2547969 | 0.76 | FYN (0.44) | CDK8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376426-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-9284300-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2016-03-15 | — | — | US | disclosed |
| US-20150011534-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-08 | — | — | US | disclosed |
| US-8927540-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| US-8921357-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-12-30 | — | — | US | disclosed |
| US-8877751-B2 | Benzothiazolone derivatives | MERCK PATENT GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-8859547-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8853211-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
| US-8580781-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2013-11-12 | — | — | US | disclosed |
| US-8211886-B2 | Thiadiazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-07-03 | — | — | US | disclosed |
| US-8071593-B2 | 2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumours | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-12-06 | — | — | US | disclosed |
| US-20110269765-A1 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110263596-A1 | 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS | SCHADT OLIVER | 2011-10-27 | — | — | US | disclosed |
| US-20110135600-A1 | BICYCLIC TRAIZOLE DERIVATIVES FOR TREATING OF TUMORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG | 2011-06-09 | — | — | US | disclosed |
| US-20100311733-A1 | THIADIAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT ESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100280030-A1 | 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-04 | — | — | US | disclosed |
| US-20100273796-A1 | 2-BENZYLPYRIDAZINONE DERIVATIVES AS MET KINASE INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-10-28 | — | — | US | disclosed |
| US-20100234354-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273796-A1 | 2-BENZYLPYRIDAZINONE DERIVATIVES AS MET KINASE INHIBITORS | ERBB2, RET, MET | CDK8 588/4885GABRG2 1020/4885GABRB3 1369/4885 |
| US-20100280030-A1 | 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS | ERBB2, RET, MET | CDK8 355/4885GABRG2 1402/4885GABRB3 932/4885 |
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MET, RET, ERBB2 | CDK8 175/4885GABRG2 2584/4885GABRB3 2748/4885 |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | RET, JAK2, MET | CDK8 355/4885GABRG2 1533/4885GABRB3 1333/4885 |
| US-20110263596-A1 | 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS | MET, RET, ERBB2 | CDK8 92/4885GABRG2 1088/4885GABRB3 607/4885 |
| US-20100311733-A1 | THIADIAZINONE DERIVATIVES | MET, ABL1, RET | CDK8 311/4885GABRG2 2303/4885GABRB3 2863/4885 |
| US-20150011534-A1 | PYRIDAZINONE DERIVATIVES | MET, RET, ERBB2 | CDK8 202/4885GABRG2 2979/4885GABRB3 3120/4885 |
| US-20110269765-A1 | Pyridazinone derivatives | MET, RET, ERBB2 | CDK8 175/4885GABRG2 2584/4885GABRB3 2748/4885 |
| US-20110135600-A1 | BICYCLIC TRAIZOLE DERIVATIVES FOR TREATING OF TUMORS | RET, BMX, ERBB2 | CDK8 752/4885GABRG2 1442/4885GABRB3 1429/4885 |
| US-20100234354-A1 | PYRIDAZINONE DERIVATIVES | MET, RET, ERBB2 | CDK8 201/4885GABRG2 2669/4885GABRB3 2845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.