Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.73 |
| ▸ | REN | P00797 | 7/20 | 0.73 |
| ▸ | CTSD | P07339 | 7/20 | 0.73 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.73 |
| ▸ | APP | P05067 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13017248 | 0.90 | BACE1 (0.69) | BACE1RENCTSDBACE2APP | |
| SCHEMBL13016945 | 0.90 | BACE1 (0.60) | BACE1RENCTSDBACE2APP | |
| SCHEMBL13016935 | 0.88 | BACE1 (0.71) | BACE1RENCTSDBACE2APP | |
| SCHEMBL2793506 | 0.84 | BACE1 (1.00) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL2794139 | 0.84 | BACE1 (1.00) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL14201206 | 0.81 | APP (0.72) | BACE1RENCTSDBACE2APP | |
| SCHEMBL3456361 | 0.79 | APP (0.75) | BACE1RENCTSDBACE2APP | |
| SCHEMBL13016932 | 0.79 | APP (0.68) | BACE1RENCTSDBACE2APP | |
| SCHEMBL13016942 | 0.79 | BACE1 (0.72) | BACE1RENCTSDBACE2APP | |
| SCHEMBL13016924 | 0.79 | BACE1 (0.59) | BACE1RENCTSDBACE2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256107-A1 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds as inhibitors of the beta-secretase (BACE) | Wyeth LLC (US) | 2010-12-01 | — | — | EP | disclosed |
| WO-2007038271-A9 | AMINO-5- [4- (DIFLUOROMETHOXY) PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS AS INHIBITORS OF THE BETA-SECRETASE (BACE) | WYETH CORP (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2007038271-A1 | AMINO-5- [4- (DIFLUOROMETHOXY) PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS AS INHIBITORS OF THE BETA-SECRETASE (BACE) | WYETH (US) | 2007-04-05 | — | — | WO | disclosed |