Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22616998 | 0.77 | HRH3 (0.48) | HRH3HRH4ROCK1 | |
| SCHEMBL13018708 | 0.71 | HRH3 (0.55) | HRH3HRH4ROCK1CDC7CDK2 | |
| SCHEMBL25481832 | 0.70 | HRH3 (0.50) | HRH3HRH4ROCK1 | |
| SCHEMBL25481828 | 0.70 | HRH3 (0.50) | HRH3HRH4ROCK1 | |
| SCHEMBL25481443 | 0.70 | HRH3 (0.50) | HRH3HRH4ROCK1 | |
| SCHEMBL7391751 | 0.70 | HSD11B1 (0.42) | — | |
| SCHEMBL3784623 | 0.69 | HRH3 (1.00) | HRH3HRH4ROCK1 | |
| SCHEMBL17626780 | 0.69 | HRH3 (0.81) | HRH3HRH4ROCK1MAP3K14 | |
| SCHEMBL17626798 | 0.69 | HRH3 (0.64) | HRH3HRH4ROCK1 | |
| Hydrochloric Acid SCHEMBL9005386 | 0.69 | HSD11B1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | HRH3 3/4885HRH4 2/4885ROCK1 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.