Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL88072 | 0.92 | GSK3B (0.71) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL88070 | 0.91 | GSK3B (0.70) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL88048 | 0.87 | GSK3B (0.70) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL88051 | 0.87 | GSK3B (0.70) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL87926 | 0.84 | GSK3B (0.65) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL83089 | 0.84 | GSK3B (0.74) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL83766 | 0.81 | GSK3B (0.72) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL88515 | 0.81 | GSK3B (0.79) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL1136421 | 0.81 | GSK3B (0.79) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL12330413 | 0.80 | GSK3B (0.67) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266969-A2 | 6-(Pyridinyl)-4-pyrimidone derivatives as tau protein kinase 1 inhibitors | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-12-29 | — | — | EP | disclosed |