SCHEMBL130264

SCHEMBL130264

CNc1ccc(C(F)(F)F)cc1

nearest known ligand 0.86

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 7/20 0.86
EPHX2 P34913 1/20 0.52
CA1 P00915 2/20 0.48
CA2 P00918 1/20 0.48
TRPV1 Q8NER1 1/20 0.46
CA12 O43570 1/20 0.44
MMP2 P08253 1/20 0.44
TGM2 P21980 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
TSHR P16473 2/20 0.43
ALDH1A1 P00352 2/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
DHODH Q02127 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodide SCHEMBL29203651 0.97 KIF11 (0.83) KIF11EPHX2CA1CA2TRPV1
Hydrochloric Acid SCHEMBL27956160 0.97 KIF11 (0.83) KIF11EPHX2CA1CA2TRPV1
Hydrochloric Acid SCHEMBL27956162 0.97 KIF11 (0.83) KIF11EPHX2CA1CA2TRPV1
SCHEMBL5428301 0.93 KIF11 (1.00) KIF11EPHX2CA1CA2
SCHEMBL19822993 0.87 KIF11 (0.68) KIF11EPHX2CA1CA2TRPV1
SCHEMBL14311924 0.83 KIF11 (0.63) KIF11EPHX2CA1CA2TRPV1
SCHEMBL22298750 0.82 KIF11 (0.61) KIF11CA1CA2ALDH1A1
SCHEMBL22198310 0.82 KIF11 (0.61) KIF11EPHX2TRPV1NPC1RAB9A
SCHEMBL12024617 0.82 KIF11 (0.61) KIF11EPHX2CA1CA2TRPV1
SCHEMBL22270553 0.81 KIF11 (0.70) KIF11EPHX2TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 513 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240277693-A1 A PHARMACEUTICAL PRODUCT CONTAINING TASQUINIMOD AND A METHOD FOR ASSESSING THE PURITY OF SAID PRODUCT ACTIVE BIOTECH AB (SE) 2024-08-22 US claimed
CN-117886718-B Preparation method of high-selectivity asymmetric urea compound and asymmetric urea compound 内蒙古工业大学 2024-05-24 CN claimed
EP-4363404-A1 A PHARMACEUTICAL PRODUCT CONTAINING TASQUINIMOD AND A METHOD FOR ASSESSING THE PURITY OF SAID PRODUCT Active Biotech AB (SE) 2024-05-08 EP claimed
CN-117886718-A Preparation method of high-selectivity asymmetric urea compound and asymmetric urea compound 内蒙古工业大学 2024-04-16 CN claimed
CN-117500790-A Pharmaceutical product containing taquinimod and method for evaluating purity of said product 活跃生物技术有限公司 2024-02-02 CN claimed
CN-110698432-B Benzyl piperazine compound, preparation method thereof and application thereof in antivirus 中国医学科学院医药生物技术研究所 2023-02-03 CN claimed
WO-2023275248-A1 A PHARMACEUTICAL PRODUCT CONTAINING TASQUINIMOD AND A METHOD FOR ASSESSING THE PURITY OF SAID PRODUCT ACTIVE BIOTECH AB (SE) 2023-01-05 WO claimed
CN-112209847-B Method for preparing amide compound under catalysis of ionic liquid in high-pressure environment 烟台大学 2022-12-23 CN claimed
CN-112209847-A Method for preparing amide compound under catalysis of ionic liquid in high-pressure environment 烟台大学 2021-01-12 CN claimed
CN-110128340-B Synthesis method of quinolinone compounds 绍兴文理学院 2020-10-30 CN claimed
US-9216956-B2 Deuterium-enriched 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide ACTIVE BIOTECH AB (SE) 2015-12-22 US claimed
CN-103796654-A Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide ACTIVE BIOTECH AB 2014-05-14 CN claimed
EP-2723340-A1 DEUTERIUM-ENRICHED 4-HYDROXY-5-METHOXY-N,1-DIMETHYL-2-OXO-N-[(4-TRIFLUORO-METHYL)PHENYL]-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE Active Biotech AB (SE) 2014-04-30 EP claimed
US-20140112946-A1 DEUTERIUM-ENRICHED 4-HYDROXY-5-METHOXY-N,1-DIMETHYL-2-OXO-N-[(4-TRIFLUORO-METHYL)PHENYL]-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE ACTIVE BIOTECH AB (SE) 2014-04-24 US claimed
WO-2012175541-A1 DEUTERIUM-ENRICHED 4-HYDROXY-5-METHOXY-N,1-DIMETHYL-2-OXO-N-[(4-TRIFLUORO-METHYL)PHENYL]-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE ACTIVE BIOTECH AB (SE) 2012-12-27 WO claimed
EP-2537517-A1 Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide Active Biotech AB (SE) 2012-12-26 EP claimed
WO-2011058577-A1 PROCESS FOR SYNTHESIZING POLYHALOGENATED PERHALOALKYLANILINE COMPOUNDS GHARDA KEKI HORMUSJI (IN) 2011-05-19 WO claimed
US-7943605-B2 Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses UCB PHARMA S.A. (BE) 2011-05-17 US claimed
US-20090023708-A1 Compounds Comprising a Lactam or a Lactam Derivative Moiety, Processes for Making Them, and Their Uses UCB PHARMA, S.A. (BE) 2009-01-22 US claimed
EP-1519932-B1 BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY CYCLACEL LTD (GB) 2007-10-03 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023708-A1 Compounds Comprising a Lactam or a Lactam Derivative Moiety, Processes for Making Them, and Their Uses COASY, FURIN, PEPD KIF11 3429/4885EPHX2 1624/4885CA1 3317/4885
US-20140112946-A1 DEUTERIUM-ENRICHED 4-HYDROXY-5-METHOXY-N,1-DIMETHYL-2-OXO-N-[(4-TRIFLUORO-METHYL)PHENYL]-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE H1-5, MALT1, H1-4 KIF11 3733/4885EPHX2 3176/4885CA1 2733/4885
US-20240277693-A1 A PHARMACEUTICAL PRODUCT CONTAINING TASQUINIMOD AND A METHOD FOR ASSESSING THE PURITY OF SAID PRODUCT TPMT, TLR7, MYD88 KIF11 1870/4885EPHX2 3424/4885CA1 4783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.