Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13031078 | 0.92 | POLB (0.36) | L3MBTL1KDM4EALDH1A1HPGDPOLB | |
| SCHEMBL13029762 | 0.90 | TSHR (0.44) | L3MBTL1KDM4EALDH1A1POLBTSHR | |
| SCHEMBL13030327 | 0.86 | L3MBTL1 (0.49) | L3MBTL1KDM4EALDH1A1HPGDPOLB | |
| SCHEMBL8231867 | 0.84 | MRGPRX1 (0.30) | TSHRMRGPRX1 | |
| SCHEMBL13029771 | 0.83 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1POLBTSHRMEN1 | |
| SCHEMBL13031103 | 0.82 | AKR1B1 (0.39) | POLBMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL8231859 | 0.77 | MDM2 (0.41) | MEN1KMT2ASMN1; SMN2MDM2HDAC1 | |
| SCHEMBL13029765 | 0.75 | TSHR (0.42) | L3MBTL1KDM4EALDH1A1POLBTSHR | |
| SCHEMBL13029671 | 0.72 | GAA (0.32) | ALDH1A1TSHRKMT2AMDM2HDAC1 | |
| SCHEMBL13031080 | 0.72 | MDM2 (0.33) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851626-B2 | 4,4,5,5, tetrasubstituted imidazolines | HOFFMANN-LA ROCHE INC. (US) | 2010-12-14 | — | — | US | disclosed |