SCHEMBL1302976

SCHEMBL1302976

O=C(O)CC1C(=O)Nc2ccccc21

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.69
IDO1 P14902 7/20 0.61
TDO2 P48775 3/20 0.61
GSK3B P49841 2/20 0.53
GLA P06280 1/20 0.53
HSD17B10 Q99714 1/20 0.53
MAPT P10636 3/20 0.49
KDM4E B2RXH2 2/20 0.49
GAA P10253 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
MEN1 O00255 1/20 0.49
NPC1 O15118 1/20 0.49
ALDH1A1 P00352 1/20 0.49
TP53 P04637 1/20 0.49
HPGD P15428 1/20 0.49
ALOX15 P16050 1/20 0.49
MAPK1 P28482 1/20 0.49
RAB9A P51151 1/20 0.49
KMT2A Q03164 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29437202 1.00 EGFR (0.69) EGFRIDO1TDO2GSK3BGLA
SCHEMBL3201173 0.89 EGFR (0.65) EGFRIDO1TDO2HSD17B10MAPT
Oxindole SCHEMBL1460829 0.86 AHR (0.54) EGFRIDO1TDO2GSK3BGLA
SCHEMBL14555787 0.85 IDO1 (0.57) EGFRIDO1TDO2GSK3BMAPT
SCHEMBL6925979 0.85 IDO1 (0.57) EGFRIDO1TDO2GSK3BMAPT
SCHEMBL28573199 0.85 IDO1 (0.64) EGFRIDO1TDO2GSK3BHSD17B10
SCHEMBL5380593 0.83 EGFR (0.70) EGFRIDO1TDO2GSK3BMAPT
SCHEMBL1388509 0.81 EGFR (1.00) EGFRIDO1TDO2GLAHSD17B10
SCHEMBL5879507 0.81 EGFR (0.61) EGFRIDO1TDO2GSK3BGLA
SCHEMBL8998981 0.81 EGFR (0.72) EGFRIDO1TDO2GSK3BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4424365-A2 PET FOOD COMPOSITIONS Hill's Pet Nutrition, Inc. (US) 2024-09-04 EP claimed
EP-4017281-B1 PET FOOD COMPOSITIONS HILLS PET NUTRITION INC (US) 2024-08-28 EP claimed
CN-117683845-A New use of small molecular substances for enhancing intestinal fatty acid absorption and screening method 浙江大学 2024-03-12 CN claimed
CN-116794202-A Screening and application of metabolic markers of rifampicin drug-resistant tuberculosis 首都医科大学附属北京胸科医院 2023-09-22 CN claimed
US-11758928-B2 Compositions and methods that modulate phosphorus or enzymes in a companion animal Société des Produits Nestlé S.A. (CH) 2023-09-19 US claimed
EP-3554258-B1 COMPOSITIONS AND METHODS THAT MODULATE PHOSPHORUS OR ENZYMES IN A COMPANION ANIMAL NESTLE SA (CH) 2023-07-19 EP claimed
CN-114828648-A Pet food compositions 希尔氏宠物营养品公司 2022-07-29 CN claimed
EP-4017281-A1 PET FOOD COMPOSITIONS Hill's Pet Nutrition, Inc. (US) 2022-06-29 EP claimed
WO-2021127701-A1 PET FOOD COMPOSITIONS HILL'S PET NUTRITION, INC. (US) 2021-06-24 WO claimed
EP-3554258-A1 COMPOSITIONS AND METHODS THAT MODULATE PHOSPHORUS OR ENZYMES IN A COMPANION ANIMAL Société des Produits Nestlé S.A. (CH) 2019-10-23 EP claimed
WO-2018109668-A1 COMPOSITIONS AND METHODS THAT MODULATE PHOSPHORUS OR ENZYMES IN A COMPANION ANIMAL NESTEC SA (CH) 2018-06-21 WO claimed
US-20160331725-A1 USE OF COMPOUNDS THAT ARE ABLE TO INCREASE THE SERUM IGF-1 LEVEL FOR THE PREPARATION OF A THERAPEUTICAL COMPOSITION FOR TREATMENT OF VARIOUS DISEASE STATES ASSOCIATED WITH A REDUCED IGF-1 SERUM LEVEL IN HUMANS AND ANIMALS VEIJLEN N.V. 2016-11-17 US claimed
US-20150065366-A1 Biomarkers for Bladder Cancer and Methods Using the Same METABOLON, INC. 2015-03-05 US claimed
EP-2776832-A1 BIOMARKERS FOR BLADDER CANCER AND METHODS USING THE SAME Metabolon, Inc. (US) 2014-09-17 EP claimed
WO-2013070839-A1 BIOMARKERS FOR BLADDER CANCER AND METHODS USING THE SAME METABOLON, INC. (US) 2013-05-16 WO claimed
JP-4641942-B2 2011-03-02 JP claimed
US-20080194553-A1 compounds that are capable of increasing the serum level of insulin-like growth factor 1 (IGF-1) for the preparation of a therapeutical composition,in the form of a food supplement, for the treatment of subjects suffering from serious fatigue and exhausting symptoms, burn-out and chronic fatigue syndrome VEIJLEN N.V. (NL) 2008-08-14 US claimed
EP-1670444-A2 USE OF INDOLEACETIC ACID DERIVATIVES WHICH INCREASE THE SERUM IGF-1 LEVEL FOR THE PREPARATION OF A THERAPEUTICAL COMPOSITION FOR TREATMENT OF VARIOUS DISEASES Veijlen N.V. (AN) 2006-06-21 EP claimed
WO-2005039546-A2 USE OF INDOLEACETIC ACID DERIVATIVES WHICH INCREASE THE SERUM IGF-1 LEVEL FOR THE PREPARATION OF A THERAPEUTICAL COMPOSITION FOR TREATMENT OF VARIOUS DISEASES VEIJLEN N.V. (AN) 2005-05-06 WO claimed
US-5849756-A Pharmaceutical composition and method for modulating the immune reaction CERBIOS-PHARMA SA (CH) 1998-12-15 US claimed