Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483325 | 0.90 | CYP2A6 (0.53) | CYP2A6ALDH1A1MAPTHPGDGFER | |
| SCHEMBL13159520 | 0.80 | CYP2A6 (0.49) | SCN4ALTA4HCYP2A6SCN2ASCN10A | |
| SCHEMBL17269665 | 0.80 | SCN2A (0.61) | SCN4ACYP2A6SCN2ASCN10AMAPT | |
| SCHEMBL15747113 | 0.75 | CYP2A6 (0.56) | CYP2A6SCN2AALDH1A1MAPTHPGD | |
| SCHEMBL17066735 | 0.73 | CYP2A6 (0.55) | CYP2A6SCN2AALDH1A1MAPTGFER | |
| SCHEMBL17066723 | 0.73 | CYP2A6 (0.55) | CYP2A6SCN2AALDH1A1MAPTGFER | |
| SCHEMBL13115506 | 0.73 | SCN2A (0.75) | SCN2ASCN10A | |
| SCHEMBL24427567 | 0.72 | CYP2A6 (0.53) | LTA4HCYP2A6SCN2ASCN10AALDH1A1 | |
| SCHEMBL7904690 | 0.72 | POLB (0.61) | LTA4HCYP2A6SCN2ASCN10ASCN5A | |
| SCHEMBL28559389 | 0.72 | CYP2A6 (0.53) | CYP2A6SCN2ASCN10AGFERPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266960-B1 | Aryl-substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles as anticonvulsants | EURO CELTIQUE SA (LU) | 2014-01-22 | — | — | EP | disclosed |
| EP-2266960-A2 | Aryl-substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles as anticonvulsants | EURO-CELTIQUE S.A. (LU) | 2010-12-29 | — | — | EP | disclosed |
| EP-1173169-B1 | ARYL SUBSTITUTED PYRAZOLES, IMIDAZOLES, OXAZOLES, THIAZOLES AND PYRROLES, AND THE USE THEREOF | EURO CELTIQUE SA (LU) | 2010-05-12 | — | — | EP | disclosed |