SCHEMBL1303244

SCHEMBL1303244

O=C(O)CCCN1C(=O)CC(O)C1=O

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 4/20 0.42
PTGS2 P35354 4/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
GAA P10253 2/20 0.42
MAPK1 P28482 2/20 0.38
CYP1A2 P05177 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CASP1 P29466 1/20 0.38
HSD17B10 Q99714 1/20 0.38
ALDH1A1 P00352 2/20 0.36
FOLH1 Q04609 1/20 0.35
PKM P14618 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15094159 0.93 PTGS1 (0.51) PTGS1PTGS2MEN1KMT2AGAA
SCHEMBL8215472 0.93 PTGS1 (0.51) PTGS1PTGS2MEN1KMT2AGAA
SCHEMBL9291270 0.93 PTGS1 (0.51) PTGS1PTGS2MEN1KMT2AGAA
Succinimide SCHEMBL28223747 0.90 MEN1 (0.36) PTGS1PTGS2MEN1KMT2AGAA
SCHEMBL3902971 0.89 MAPK1 (0.47) MEN1KMT2AGAAMAPK1CYP1A2
SCHEMBL3877414 0.85 CYP19A1 (0.41) MEN1KMT2AGAAMAPK1SMN1; SMN2
SCHEMBL1325053 0.83 CYP19A1 (0.42) MEN1KMT2AGAAMAPK1SMN1; SMN2
SCHEMBL22571074 0.79 CYP19A1 (0.51) PTGS1PTGS2MEN1KMT2AGAA
SCHEMBL22571073 0.79 CYP19A1 (0.51) PTGS1PTGS2MEN1KMT2AGAA
SCHEMBL5919521 0.78 TSHR (0.49) MEN1KMT2AGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007501812-A 2007-02-01 JP claimed
US-20060182714-A1 Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides NOVO NORDISK A/S (DK) 2006-08-17 US claimed
EP-1654004-A2 SYNTHESIS AND APPLICATION OF NEW STRUCTURAL WELL DEFINED BRANCHED POLYMERS AS CONJUGATING AGENTS FOR PEPTIDES NOVO NORDISK A/S (DK) 2006-05-10 EP claimed
WO-2005014049-A2 SYNTHESIS AND APPLICATION OF NEW STRUCTURAL WELL DEFINED BRANCHED POLYMERS AS CONJUGATING AGENTS FOR PEPTIDES NOVO NORDISK A/S (DK) 2005-02-17 WO claimed
CN-105573054-A COMPOUND AND COLORED CURABLE RESIN COMPOSITION SUMITOMO CHEMICAL CO 2016-05-11 CN disclosed
CN-105315722-A Salified dye and coloring curable resin composition SUMITOMO CHEMICAL CO 2016-02-10 CN disclosed
US-8053410-B2 Pegylated factor VII glycoforms NOVO NORDISK HEALTH CARE A/G (CH) 2011-11-08 US disclosed
EP-1517710-B1 PEGYLATED FACTOR VII GLYCOFORMS NOVO NORDISK HEALTHCARE AG (CH) 2011-03-30 EP disclosed
US-20090240028-A1 Synthesis and Application of New Structural Well Defined Branched Polymers as Conjugating Agents for Peptides NOVO NORDISK A/S (DK) 2009-09-24 US disclosed
US-20090227504-A1 Pegylated Factor VII Glycoforms NOVO NORDISK A/S (DK) 2009-09-10 US disclosed
US-20080039373-A1 Pegylated Factor VII Glycoforms NOVO NORDISK A/S (DK) 2008-02-14 US disclosed
US-20060182714-A1 Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides NOVO NORDISK A/S (DK) 2006-08-17 US disclosed
EP-1654004-A2 SYNTHESIS AND APPLICATION OF NEW STRUCTURAL WELL DEFINED BRANCHED POLYMERS AS CONJUGATING AGENTS FOR PEPTIDES NOVO NORDISK A/S (DK) 2006-05-10 EP disclosed
US-20050113565-A1 Pegylated factor VII glycoforms KLAUSEN NIELS K (DK) 2005-05-26 US disclosed
EP-1517710-A1 PEGYLATED FACTOR VII GLYCOFORMS Novo Nordisk Health Care AG (CH) 2005-03-30 EP disclosed
WO-2005014049-A2 SYNTHESIS AND APPLICATION OF NEW STRUCTURAL WELL DEFINED BRANCHED POLYMERS AS CONJUGATING AGENTS FOR PEPTIDES NOVO NORDISK A/S (DK) 2005-02-17 WO disclosed
WO-2004000366-A1 PEGYLATED FACTOR VII GLYCOFORMS NOVO NORDISK HEALTH CARE AG (CH) 2003-12-31 WO disclosed
US-6372813-B1 CROSSLINKING POLYACRYLAMIDE HYDROGEL, JOINING BIOMOLECULES ON SUPPORTS MOTOROLA 2002-04-16 US disclosed
US-5354871-A Pyrroline N-oxide derivatives NATIONAL RESEARCH COUNCIL OF CANADA (CA) 1994-10-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227504-A1 Pegylated Factor VII Glycoforms F7, F13B, F5 PTGS1 4063/4885PTGS2 4142/4885MEN1 2340/4885
US-20060182714-A1 Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides VIP, PTMS, PDGFA PTGS1 3587/4885PTGS2 3691/4885MEN1 1142/4885
US-20090240028-A1 Synthesis and Application of New Structural Well Defined Branched Polymers as Conjugating Agents for Peptides VIP, PTMS, PDGFA PTGS1 3587/4885PTGS2 3691/4885MEN1 1142/4885
US-20050113565-A1 Pegylated factor VII glycoforms F7, F13B, F5 PTGS1 4063/4885PTGS2 4142/4885MEN1 2340/4885
US-20080039373-A1 Pegylated Factor VII Glycoforms F7, F13B, F5 PTGS1 4063/4885PTGS2 4142/4885MEN1 2340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.