Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 13/20 | 0.54 |
| ▸ | CALCA | P06881 | 7/20 | 0.47 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12990523 | 0.88 | CALCRL (0.51) | CALCRLCALCARAMP1 | |
| SCHEMBL13376823 | 0.85 | CALCRL (0.57) | CALCRLRAMP1 | |
| SCHEMBL13034492 | 0.81 | CALCA (0.51) | CALCRLCALCARAMP1 | |
| SCHEMBL13034499 | 0.80 | CALCA (0.52) | CALCRLCALCARAMP1 | |
| SCHEMBL13034485 | 0.80 | CALCA (0.54) | CALCRLCALCA | |
| SCHEMBL3526238 | 0.80 | CALCA (0.54) | CALCRLCALCA | |
| SCHEMBL14536055 | 0.79 | CALCRL (0.53) | CALCRLCALCA | |
| SCHEMBL1393838 | 0.78 | CALCA (0.60) | CALCRLCALCA | |
| SCHEMBL1393840 | 0.78 | CALCA (0.60) | CALCRLCALCA | |
| SCHEMBL13083798 | 0.78 | CALCA (0.51) | CALCRLCALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954135-B1 | SPIROLACTAM ARYL CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-10-10 | — | — | EP | disclosed |
| US-7851464-B2 | Spirolactam aryl CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-12-14 | — | — | US | disclosed |
| US-20090247514-A1 | Spirolactam aryl cgrp receptor antagonists | MERCK SHARP & DOHME LLC | 2009-10-01 | — | — | US | disclosed |
| US-20090247514-A1 | Spirolactam aryl cgrp receptor antagonists | MERCK SHARP & DOHME LLC | 2009-10-01 | — | — | US | disclosed |
| WO-2007061677-A2 | SPIROLACTAM ARYL CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247514-A1 | Spirolactam aryl cgrp receptor antagonists | CALCRL, BDKRB1, CALCR | CALCRL 1/4885CALCA 5/4885RAMP1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.