Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.83 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.83 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 9/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pixantrone SCHEMBL29372192 | 0.93 | ECE1 (0.72) | ECE1MUS81KDM4CMAOAMAOB | |
| Pixantrone SCHEMBL7825 | 0.93 | ECE1 (0.72) | ECE1MUS81KDM4CMAOAMAOB | |
| Pixantrone SCHEMBL17673194 | 0.92 | ECE1 (0.70) | ECE1MUS81KDM4CMAOAMAOB | |
| Pixantrone SCHEMBL7771183 | 0.92 | ECE1 (0.70) | ECE1MUS81KDM4CMAOAMAOB | |
| SCHEMBL13524774 | 0.90 | ECE1 (0.68) | ECE1MUS81KDM4CMAOAMAOB | |
| SCHEMBL28381205 | 0.87 | ECE1 (0.65) | ECE1MUS81KDM4CMAOAMAOB | |
| SCHEMBL29642208 | 0.87 | ECE1 (0.65) | ECE1MUS81KDM4CMAOAMAOB | |
| SCHEMBL29642192 | 0.87 | ECE1 (0.65) | ECE1MUS81KDM4CMAOAMAOB | |
| SCHEMBL28887626 | 0.87 | ECE1 (0.65) | ECE1MUS81KDM4CMAOAMAOB | |
| SCHEMBL29642322 | 0.87 | ECE1 (0.65) | ECE1MUS81KDM4CMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292231-A1 | Indazole Compounds for Treating Inflammatory Disorders, Demyelinating Disorders and Cancers | AJAMI ALFRED M | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292231-A1 | Indazole Compounds for Treating Inflammatory Disorders, Demyelinating Disorders and Cancers | FLT3, CSF3R, CSF1R | ECE1 3774/4885MUS81 4686/4885KDM4C 3910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.