Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.59 |
| ▸ | PIK3R2 | O00459 | 17/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 17/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.59 |
| ▸ | PIK3R5 | Q8WYR1 | 17/20 | 0.59 |
| ▸ | PIK3R3 | Q92569 | 17/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13194 | 0.89 | PIK3CD (0.54) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13078 | 0.82 | PIK3CD (0.53) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13142 | 0.82 | PIK3CD (0.62) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13251 | 0.82 | PIK3CD (0.66) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12276125 | 0.81 | PIK3CD (0.87) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13410 | 0.80 | PIK3CD (0.66) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13038 | 0.79 | CYP1A2 (0.43) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082742 | 0.79 | PIK3CD (0.64) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082790 | 0.77 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082814 | 0.77 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |