Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.54 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13714673 | 0.97 | CYP3A4 (0.59) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL13714668 | 0.97 | CYP3A4 (0.59) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL13714872 | 0.97 | CYP3A4 (0.59) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL13714894 | 0.91 | CYP3A4 (0.68) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL29542259 | 0.91 | CYP3A4 (0.68) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL13714667 | 0.89 | CYP3A4 (0.49) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL13714733 | 0.89 | CYP3A4 (0.49) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL13714665 | 0.89 | CYP3A4 (0.49) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL13714671 | 0.87 | CYP3A4 (0.58) | CYP3A4ALDH1A1KDM4ETDP1BACE1 | |
| SCHEMBL13714670 | 0.87 | CYP3A4 (0.58) | CYP3A4ALDH1A1KDM4ETDP1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100291034-A1 | COMBINATIONS OF HCV PROTEASE INHIBITOR(S) AND CYP3A4 INHIBITOR(S), AND METHODS OF TREATMENT RELATED THERETO | SCHERING CORPORATION (US) | 2010-11-18 | — | — | US | disclosed |
| US-20070287664-A1 | Combinations of HCV protease inhibitor(s) and CYP3A4 inhibitor(s), and methods of treatment related thereto | SCHERING CORPORATION | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287664-A1 | Combinations of HCV protease inhibitor(s) and CYP3A4 inhibitor(s), and methods of treatment related thereto | CYP3A43, CYP3A4, CYP3A7 | CYP3A4 2/4885ALDH1A1 653/4885KDM4E 3585/4885 |
| US-20100291034-A1 | COMBINATIONS OF HCV PROTEASE INHIBITOR(S) AND CYP3A4 INHIBITOR(S), AND METHODS OF TREATMENT RELATED THERETO | CYP3A43, CYP3A4, CYP3A7 | CYP3A4 2/4885ALDH1A1 653/4885KDM4E 3585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.