Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14898577 | 0.95 | TSHR (0.52) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL1115450 | 0.95 | TSHR (0.52) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL10086309 | 0.92 | CES1 (0.52) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL11155708 | 0.91 | CES1 (0.55) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL14898590 | 0.91 | CES1 (0.50) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL1238411 | 0.91 | CES1 (0.55) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL2018151 | 0.91 | CES1 (0.55) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL19463076 | 0.91 | CES1 (0.55) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL17563456 | 0.91 | TSHR (0.48) | TSHRCES1THRBMEN1HTT | |
| SCHEMBL13039015 | 0.91 | TSHR (0.48) | TSHRCES1THRBMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299200-B2 | Anchored polysiloxane-modified polyurethane coatings and uses thereof | NDSU RESEARCH FOUNDATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-20100280148-A1 | ANCHORED POLYSILOXANE-MODIFIED POLYURETHANE COATINGS AND USES THEREOF | NDSU RESEARCH FOUNDATION | 2010-11-04 | — | — | US | disclosed |
| US-7820693-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-10-26 | — | — | US | disclosed |
| US-20090030195-A1 | 1-(2H)-ISOQUINOLONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030195-A1 | 1-(2H)-ISOQUINOLONE DERIVATIVE | NQO1, NR5A1, SRD5A1 | TSHR 4285/4885CES1 478/4885THRB 2932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.