Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | CDK9 | P50750 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13039364 | 0.82 | PIK3C3 (0.49) | EIF2AK2MAPK1CDK2CDK9CDK1 | |
| SCHEMBL13039360 | 0.81 | EIF2AK2 (0.47) | EIF2AK2CYP1A2CLK4CYP3A4HSD17B10 | |
| SCHEMBL13039359 | 0.81 | HRH4 (0.44) | EIF2AK2CDK2CDK9CCNT1CCNA2 | |
| SCHEMBL13039325 | 0.80 | MKNK1 (0.51) | EIF2AK2CDK2CDK9CCNT1CCNA2 | |
| SCHEMBL13039329 | 0.79 | BRAF (0.41) | EIF2AK2CDK2CDK9CCNT1CCNA2 | |
| SCHEMBL13039341 | 0.79 | EIF2AK2 (0.55) | EIF2AK2CLK4HSD17B10CDK2CDK9 | |
| SCHEMBL13039322 | 0.78 | CCNT1 (0.60) | EIF2AK2CDK2CDK9CCNT1CCNA2 | |
| SCHEMBL13039361 | 0.78 | MKNK1 (0.44) | EIF2AK2MKNK1 | |
| SCHEMBL13039379 | 0.77 | EIF2AK2 (0.40) | EIF2AK2MAPK1CCNT1BRAF | |
| SCHEMBL13039330 | 0.77 | HTR7 (0.50) | EIF2AK2ALDH1A1CDK2CDK9CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367687-B2 | Pyrazole derivatives | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| US-8367687-B2 | Pyrazole derivatives | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| US-20100280033-A1 | Pyrazole Derivatives | NOVARTIS AG | 2010-11-04 | — | — | US | disclosed |
| US-20100280033-A1 | Pyrazole Derivatives | NOVARTIS AG | 2010-11-04 | — | — | US | disclosed |
| WO-2009071701-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280033-A1 | Pyrazole Derivatives | PRKDC, PRKACA, PDK2 | EIF2AK2 328/4885CYP1A2 1815/4885CLK4 755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.