⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2925272 | 0.67 | — | — | |
| SCHEMBL154932 | 0.64 | — | — | |
| SCHEMBL29740320 | 0.64 | — | — | |
| SCHEMBL1247212 | 0.62 | — | — | |
| SCHEMBL22960695 | 0.61 | — | — | |
| SCHEMBL22960697 | 0.61 | — | — | |
| Ammonia Solution, Strong SCHEMBL22960694 | 0.61 | — | — | |
| SCHEMBL533161 | 0.60 | RAB9A (0.41) | — | |
| SCHEMBL5248997 | 0.59 | — | — | |
| SCHEMBL17103382 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 520 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045468-B2 | 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin | ALBANY MOLECULAR RESEARCH, INC. (US) | 2015-06-02 | — | — | US | claimed |
| EP-2606049-A2 | 2,5-METHANO-AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | Albany Molecular Research, Inc. (US) | 2013-06-26 | — | — | EP | claimed |
| EP-1827444-B1 | MNK1 OR MNK2 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2013-05-15 | — | — | EP | claimed |
| US-20120046271-A1 | 2,5-Methano- and 2,5-Ethano-Tetrahydrobenzazepine Derivatives And Use Thereof To Block Reuptake Of Norepinephrine, Dopamine, and Serotonin | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-23 | — | — | US | claimed |
| WO-2012024397-A2 | 2,5-METHANO-AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-02-23 | — | — | WO | claimed |
| EP-2144875-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | Amira Pharmaceuticals, Inc. (US) | 2010-01-20 | — | — | EP | claimed |
| US-20090163520-A1 | MNK1 or MNK2 Inhibitors | DEVELOGEN AKTIENGESELLSCHAFT (DE) | 2009-06-25 | — | — | US | claimed |
| WO-2008137609-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | WO | claimed |
| US-7306789-B2 | Method of stimulating hair growth using benzopyrans | WARNER-LAMBERT COMPANY, LLC (US) | 2007-12-11 | — | — | US | claimed |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | US | claimed |
| EP-0726255-A2 | 3-Pyridazine derivatives and their use in rubber | MONSANTO COMPANY (US) | 1996-08-14 | — | — | EP | claimed |
| EP-0712398-A1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LTD (GB) | 1996-05-22 | — | — | EP | claimed |
| EP-0690855-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-01-10 | — | — | EP | claimed |
| WO-1995004730-A1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LIMITED (GB) | 1995-02-16 | — | — | WO | claimed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | claimed |
| CN-1085227-A | 3-pyridazine derivatives and the application in rubber thereof | MONSANTO CO (US) | 1994-04-13 | — | — | CN | claimed |
| WO-1993025537-A1 | 3-PYRIDAZINE DERIVATIVES AND THEIR USE IN RUBBER | MONSANTO COMPANY (US) | 1993-12-23 | — | — | WO | claimed |
| US-4716232-A | 1-(vinyl phosphonate adduct) pyrazolidinones | ELI LILLY AND COMPANY (US) | 1987-12-29 | — | — | US | claimed |
| US-4125611-A | MICROBIOCIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1978-11-14 | — | — | US | claimed |
| US-4061748-A | BACTERICIDE | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-12-06 | — | — | US | claimed |