Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLTP | P55058 | 15/20 | 0.74 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | DDX3X | O00571 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303534 | 0.91 | PLTP (0.74) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL1304447 | 0.85 | PLTP (0.84) | PLTPRORCADORA2AADORA1PTGDR2 | |
| SCHEMBL1303885 | 0.85 | PLTP (1.00) | PLTPRORCPTGDR2 | |
| SCHEMBL1303537 | 0.85 | PLTP (0.79) | PLTPRORCPTGDR2 | |
| SCHEMBL1303294 | 0.85 | PLTP (0.84) | PLTPRORCADORA2AADORA1PTGDR2 | |
| SCHEMBL1302909 | 0.84 | PLTP (1.00) | PLTPRORCPTGDR2 | |
| SCHEMBL1304187 | 0.81 | PLTP (0.76) | PLTPPTGDR2 | |
| SCHEMBL1303738 | 0.81 | PLTP (0.76) | PLTPADORA2AADORA1PTGDR2 | |
| SCHEMBL1305146 | 0.78 | PLTP (0.72) | PLTPADORA2AADORA1PTGDR2 | |
| SCHEMBL1303803 | 0.78 | PLTP (1.00) | PLTPRORCDGAT1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2772488-B1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | INST PHARM & TOXICOLOGY AMMS (CN) | 2016-11-02 | — | — | EP | claimed |
| EP-2042494-B1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | INST PHARM & TOXICOLOGY AMMS (CN) | 2014-07-09 | — | — | EP | claimed |
| US-8053581-B2 | Trisubstituted thiazole compounds, preparations methods, pharmaceutical compositions and medicals uses thereof | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.C. China (CN) | 2011-11-08 | — | — | US | claimed |
| CN-101096363-B | 2,4,5-three-substituted thiazole compound, preparation method, medicament composition and pharmacy use thereof | INST PHARM & TOXICOLOGY AMMS | 2011-05-11 | — | — | CN | claimed |
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2009-12-03 | — | — | US | claimed |
| EP-2042494-A1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2009-04-01 | — | — | EP | claimed |
| CN-101096363-A | 2,4,5-three-substituted thiazole compound, preparation method, medicament composition and pharmacy use thereof | POISON MED INST PLA MED ACAD (CN) | 2008-01-02 | — | — | CN | claimed |
| EP-2772488-B1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | INST PHARM & TOXICOLOGY AMMS (CN) | 2016-11-02 | — | — | EP | disclosed |
| EP-2772488-B1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | INST PHARM & TOXICOLOGY AMMS (CN) | 2016-11-02 | — | — | EP | disclosed |
| EP-2772488-A1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L. A. China (CN) | 2014-09-03 | — | — | EP | disclosed |
| EP-2772488-A1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L. A. China (CN) | 2014-09-03 | — | — | EP | disclosed |
| EP-2042494-B1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | INST PHARM & TOXICOLOGY AMMS (CN) | 2014-07-09 | — | — | EP | disclosed |
| EP-2042494-B1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | INST PHARM & TOXICOLOGY AMMS (CN) | 2014-07-09 | — | — | EP | disclosed |
| CN-101096363-B | 2,4,5-three-substituted thiazole compound, preparation method, medicament composition and pharmacy use thereof | INST PHARM & TOXICOLOGY AMMS | 2011-05-11 | — | — | CN | disclosed |
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2009-12-03 | — | — | US | disclosed |
| EP-2042494-A1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2009-04-01 | — | — | EP | disclosed |
| EP-2042494-A1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2009-04-01 | — | — | EP | disclosed |
| CN-101096363-A | 2,4,5-three-substituted thiazole compound, preparation method, medicament composition and pharmacy use thereof | POISON MED INST PLA MED ACAD (CN) | 2008-01-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | CETP, PLTP, MTTP | PLTP 2/4885RORC 1412/4885DGAT1 298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.