PLTP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL27839858	1.00	18/20
SCHEMBL28793037	1.00	18/20
SCHEMBL1303885	1.00	17/20
SCHEMBL1302909	1.00	16/20
SCHEMBL1304117	1.00	16/20
SCHEMBL1304079	1.00	15/20
SCHEMBL1305129	1.00	15/20
SCHEMBL1303294	0.84	15/20
SCHEMBL1304022	0.83	15/20
SCHEMBL1303537	0.79	15/20
SCHEMBL13892795	0.75	15/20
SCHEMBL1304014	0.74	15/20
SCHEMBL1303121	1.00	14/20
SCHEMBL1304278	1.00	14/20
SCHEMBL1304281	1.00	14/20
SCHEMBL1304571	1.00	14/20
SCHEMBL13892738	0.82	14/20
SCHEMBL1305132	0.73	14/20
SCHEMBL1304024	0.73	14/20
SCHEMBL1305127	0.66	14/20

Clinical trials — most relevant to PLTP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL)	PHASE4	COMPLETED
The HDL Particle Protection Study	PHASE4	COMPLETED
The Low HDL On Six Weeks Statin Therapy (LOW) Study	PHASE4	UNKNOWN
Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial	PHASE3	COMPLETED
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes	PHASE3	COMPLETED
Lovaza's Effect on the Activation of Platelets	PHASE2	COMPLETED
Lipid Infusion in Dialysis Patients With Endotoxemia	PHASE2	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Association Between HDL Functions and Atherosclerotic Burden in Healthy Individuals	nan	COMPLETED
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease.	nan	UNKNOWN
Effect of a Black Garlic Extract on Cholesterol LDL Levels	nan	COMPLETED
The Effect of E-EPA on Circulating LDL and Plasma Lipid Metabolism	nan	COMPLETED
The Effect of Injectable Platelet-Rich Fibrin in Peri-implant Soft Tissue	nan	RECRUITING
Association of SGLT2 Inhibitors Therapy With Elastographic and Molecular Markers of Liver Injury in Type 2 Diabetes	nan	COMPLETED
The Molecular Biology of Paroxysmal Nocturnal Hemoglobinuria (PNH)	nan	COMPLETED
Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial Hypercholesterolemia	nan	UNKNOWN
Canagliflozin on Liver Inflammation Damage in Type 2 Diabetes Patients With Nonalcoholic Fatty Liver Disease	nan	UNKNOWN
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)	nan	COMPLETED
Epidemiology of Atherosclerosis	nan	COMPLETED
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies	nan	UNKNOWN
Platelets Function and Cardiovascular Events in Patients With End Stage Renal Disease	nan	UNKNOWN
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk	nan	COMPLETED
Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy Donors	nan	COMPLETED
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: From Patients to Families	nan	RECRUITING
Egg Intake, Metabolic Outcomes and Choline Levels	nan	RECRUITING
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Lipoprotein Interactions and Platelet Function in Healthy Individuals and Those With Lipid Disorders	nan	RECRUITING
Lysosomal Acid Lipase Activity in Nonalcoholic Fatty Liver Disease	nan	COMPLETED
Choline to Improve Malnutrition and Enhance Cognition	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PLTP binder may also engage these)

Protein	Name	Similarity
P55065	—	1.000	P55065 →
P47896	—	0.996	P47896 →
Q3V6R6	—	0.994	Q3V6R6 →
Q61114	—	0.993	Q61114 →
P22687	—	0.992	P22687 →
Q8C186	—	0.992	Q8C186 →
CETP	Cholesteryl ester transfer protein	0.992	landscape →
Q8TDL5	—	0.991	Q8TDL5 →
Q8N4F0	—	0.990	Q8N4F0 →
Q2TBI0	—	0.990	Q2TBI0 →
Q61805	—	0.990	Q61805 →
Q63313	—	0.989	Q63313 →
P17454	—	0.988	P17454 →
A0JPN3	—	0.988	A0JPN3 →
Q05701	—	0.988	Q05701 →
Q8BU51	—	0.987	Q8BU51 →
G3HIK4	—	0.987	G3HIK4 →
Q6AXU0	—	0.986	Q6AXU0 →
Q67E05	—	0.985	Q67E05 →
P18428	—	0.984	P18428 →
Q8NFQ6	—	0.984	Q8NFQ6 →
P59826	—	0.982	P59826 →
Q80ZU7	—	0.981	Q80ZU7 →
Q8C1E1	—	0.981	Q8C1E1 →
Q8SPF8	—	0.978	Q8SPF8 →
Q8NFQ5	—	0.978	Q8NFQ5 →
P25914	—	0.976	P25914 →
Q28739	—	0.976	Q28739 →
P59827	—	0.975	P59827 →
A2BGH0	—	0.974	A2BGH0 →