⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14952593 | 0.75 | — | — | |
| SCHEMBL13662808 | 0.74 | — | — | |
| SCHEMBL13986784 | 0.72 | — | — | |
| SCHEMBL2200429 | 0.72 | — | — | |
| SCHEMBL30840114 | 0.72 | CYP4F2 (0.33) | — | |
| SCHEMBL23539423 | 0.70 | — | — | |
| SCHEMBL14949770 | 0.70 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL334934 | 0.70 | DUT (0.38) | — | |
| SCHEMBL3434853 | 0.69 | — | — | |
| SCHEMBL1143253 | 0.69 | DUT (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497385-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-07-30 | — | — | US | disclosed |
| US-20100280262-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-11-04 | — | — | US | disclosed |
| US-20090270492-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2009-10-29 | — | — | US | disclosed |
| US-20070270485-A1 | Byrostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2007-11-22 | — | — | US | disclosed |