Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.56 |
| ▸ | KDR | P35968 | 8/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041330 | 0.88 | FGFR1 (0.63) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL12879833 | 0.86 | FGFR1 (0.70) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL1055018 | 0.85 | FGFR1 (0.74) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL14268438 | 0.84 | CHEK1 (0.59) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL13041337 | 0.84 | FGFR1 (0.55) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL13041342 | 0.84 | FGFR1 (0.59) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL13041331 | 0.82 | FGFR1 (0.53) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL13041329 | 0.82 | FGFR1 (0.56) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL1050109 | 0.81 | CHEK1 (0.66) | CHEK1PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL14795537 | 0.78 | CHEK1 (0.63) | CHEK1PDGFRBFGFR1KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825132-B2 | Inhibition of FGFR3 and treatment of multiple myeloma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20090281100-A1 | Benzimidazole quinolinones and uses thereof | BARSANTI PAUL A | 2009-11-12 | — | — | US | disclosed |
| US-7470709-B2 | Benzimidazole quinolinones and uses thereof | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281100-A1 | Benzimidazole quinolinones and uses thereof | GAA, ALPI, IL4I1 | CHEK1 2358/4885PDGFRB 3508/4885FGFR1 3018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.