Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.53 |
| ▸ | FLT1 | P17948 | 3/20 | 0.53 |
| ▸ | PDE5A | O76074 | 4/20 | 0.52 |
| ▸ | METAP1 | P53582 | 2/20 | 0.50 |
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.42 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728541 | 0.85 | NPC1 (0.56) | FGFR1FLT1ALDH1A1PKMKDM4E | |
| SCHEMBL13042373 | 0.78 | KMT2A (0.48) | FGFR1FLT1ALDH1A1PKMKDM4E | |
| SCHEMBL13042339 | 0.77 | FGFR1 (0.48) | FGFR1FLT1ALDH1A1KDM4ENPC1 | |
| SCHEMBL13042349 | 0.76 | CBFB (0.49) | FGFR1FLT1ALDH1A1PKMKDM4E | |
| SCHEMBL13042348 | 0.75 | PDGFRB (0.40) | FGFR1FLT1METAP1METAP2ALDH1A1 | |
| SCHEMBL13042357 | 0.75 | FGFR1 (0.46) | FGFR1FLT1ALDH1A1KDM4ENPC1 | |
| SCHEMBL13042323 | 0.75 | FGFR1 (0.46) | FGFR1FLT1ALDH1A1KDM4ENPC1 | |
| SCHEMBL2312523 | 0.75 | PDE5A (0.60) | FGFR1FLT1PDE5AMETAP1METAP2 | |
| SCHEMBL13042436 | 0.74 | FGFR1 (0.46) | FGFR1FLT1 | |
| SCHEMBL13042430 | 0.74 | FGFR1 (0.48) | FGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492374-B2 | Azaazulene compounds | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2013-07-23 | — | — | US | disclosed |
| US-8492374-B2 | Azaazulene compounds | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2013-07-23 | — | — | US | disclosed |
| US-20100280012-A1 | AZAAZULENE COMPOUNDS | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2010-11-04 | — | — | US | disclosed |
| US-20100280012-A1 | AZAAZULENE COMPOUNDS | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280012-A1 | AZAAZULENE COMPOUNDS | AZI2, CYP51A1, CYP3A5 | FGFR1 1577/4885FLT1 2779/4885PDE5A 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.