Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.54 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 5/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3741822 | 0.94 | KDR (0.54) | KDRKITRAF1LCKRET | |
| SCHEMBL13043372 | 0.91 | KDR (0.52) | KDRKITRAF1LCKRET | |
| SCHEMBL13043373 | 0.91 | KDR (0.52) | KDRKITRAF1LCKRET | |
| SCHEMBL13043376 | 0.91 | KDR (0.52) | KDRKITRAF1LCKRET | |
| SCHEMBL13043403 | 0.91 | KDR (0.52) | KDRKITRAF1LCKRET | |
| SCHEMBL13043393 | 0.91 | KDR (0.52) | KDRKITRAF1LCKRET | |
| SCHEMBL13043420 | 0.90 | KDR (0.51) | KDRKITRAF1LCKRET | |
| SCHEMBL13043362 | 0.90 | KDR (0.53) | KDRKITRAF1LCKRET | |
| SCHEMBL13043400 | 0.90 | KDR (0.51) | KDRKITRAF1LCKRET | |
| SCHEMBL13043379 | 0.89 | KDR (0.51) | KDRKITRAF1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829717-B2 | (Arylamidoaryl)squaramide compounds | OSI PHARMACEUTICALS, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-7829717-B2 | (Arylamidoaryl)squaramide compounds | OSI PHARMACEUTICALS, INC. (US) | 2010-11-09 | — | — | US | disclosed |