Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.51 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3735779 | 0.94 | KDR (0.51) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043372 | 0.94 | KDR (0.52) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043393 | 0.93 | KDR (0.52) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043403 | 0.93 | KDR (0.52) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043420 | 0.92 | KDR (0.51) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043392 | 0.91 | KDR (0.48) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043389 | 0.89 | KDR (0.54) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043409 | 0.89 | KDR (0.47) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043373 | 0.89 | KDR (0.52) | KDRKITCYP3A4RAF1LCK | |
| SCHEMBL13043362 | 0.88 | KDR (0.53) | KDRKITCYP3A4RAF1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829717-B2 | (Arylamidoaryl)squaramide compounds | OSI PHARMACEUTICALS, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-7829717-B2 | (Arylamidoaryl)squaramide compounds | OSI PHARMACEUTICALS, INC. (US) | 2010-11-09 | — | — | US | disclosed |