Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 10/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302939 | 0.85 | PIK3CG (0.43) | PIK3CGPIK3CAPIK3CDPIK3CBCLK1 | |
| SCHEMBL1302534 | 0.83 | PIK3CG (0.53) | PIK3CGPIK3CAPIK3CDPIK3CBCLK1 | |
| SCHEMBL1303772 | 0.80 | PIK3CG (0.43) | PIK3CGPIK3CAPIK3CDPIK3CBCLK1 | |
| SCHEMBL3912369 | 0.80 | ROCK2 (0.44) | PIK3CGPIK3CAPIK3CDPIK3CBROCK2 | |
| SCHEMBL3688011 | 0.78 | PIK3CG (0.33) | PIK3CGPIK3CAPIK3CDPIK3CBCLK1 | |
| SCHEMBL13960257 | 0.75 | PIK3CG (0.52) | PIK3CGPIK3CAPIK3CDPIK3CBTTK | |
| SCHEMBL1304196 | 0.75 | CLK1 (0.54) | PIK3CGPIK3CAPIK3CDPIK3CBCLK1 | |
| SCHEMBL1303565 | 0.75 | PIK3CG (0.60) | PIK3CGPIK3CAPIK3CDPIK3CBTTK | |
| SCHEMBL1302544 | 0.74 | PIK3CA (0.43) | PIK3CGPIK3CAPIK3CDPIK3CBCLK1 | |
| SCHEMBL1302670 | 0.74 | MAP3K5 (0.44) | PIK3CGPIK3CAPIK3CDPIK3CBCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053574-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-11-08 | — | — | US | disclosed |
| US-20100197682-A1 | Organic Compounds | NOVARTIS AG | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197682-A1 | Organic Compounds | PIK3CA, PI4KA, PI4KB | PIK3CG 11/4885PIK3CA 1/4885PIK3CD 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.