SCHEMBL13044232

SCHEMBL13044232

O=C1NC(=O)C(=Cc2cccc(OCc3ccccc3)c2)C(=O)N1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.76
NPC1 O15118 5/20 0.76
RAB9A P51151 5/20 0.76
KMT2A Q03164 5/20 0.76
PPARG P37231 2/20 0.74
POLB P06746 3/20 0.62
TDP1 Q9NUW8 2/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
MMP13 P45452 1/20 0.62
ADAMTS5 Q9UNA0 1/20 0.62
SIRT2 Q8IXJ6 2/20 0.60
SIRT1 Q96EB6 1/20 0.60
SIRT3 Q9NTG7 1/20 0.60
SIRT5 Q9NXA8 1/20 0.60
MAOA P21397 1/20 0.59
MAOB P27338 1/20 0.59
ATM Q13315 1/20 0.57
ABL1 P00519 1/20 0.56
SRC P12931 1/20 0.56
NR1H4 Q96RI1 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13848508 0.90 SIRT2 (0.75) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL3724109 0.89 PPARG (0.78) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL15421304 0.88 GSK3B (0.70) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL15421308 0.88 GSK3B (0.70) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL15421306 0.88 GSK3B (0.70) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL25058825 0.88 KMT2A (0.63) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL15421780 0.85 PPARG (1.00) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL20772352 0.83 NPC1 (0.58) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL31338663 0.83 NPC1 (0.58) MEN1NPC1RAB9AKMT2APPARG
SCHEMBL20772147 0.82 MRGPRX4 (0.57) MEN1NPC1RAB9AKMT2APPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022245120-A1 NOVEL COMPOUND AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR INHIBITING BIOFILM FORMATION OR VIRULENCE OF PATHOGENIC MICROORGANISM 부산대학교 산학협력단 2022-11-24 WO claimed
WO-2022245120-A1 NOVEL COMPOUND AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR INHIBITING BIOFILM FORMATION OR VIRULENCE OF PATHOGENIC MICROORGANISM 부산대학교 산학협력단 2022-11-24 WO disclosed
US-9896421-B2 Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use thereof PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2018-02-20 US disclosed
US-20160102065-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2016-04-14 US disclosed
US-9216148-B2 Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use therefor PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2015-12-22 US disclosed
US-20140023603-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2014-01-23 US disclosed
WO-2010136804-A1 PYRIMIDINE DERIVATIVES FOR USE AS ANTIBIOTICS ASTON UNIVERSITY (GB) 2010-12-02 WO disclosed
EP-1305026-B1 BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS NOVUSPHARMA SPA (IT) 2009-05-13 EP disclosed
US-20080113993-A1 BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS VIA ARIOSTO, 23 (IT) 2008-05-15 US disclosed
US-20080113993-A1 BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS VIA ARIOSTO, 23 (IT) 2008-05-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140023603-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR PPARG, PPARA, PPARD MEN1 4685/4885NPC1 3207/4885RAB9A 4420/4885
US-20160102065-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF PPARG, PPARA, TYR MEN1 4838/4885NPC1 3522/4885RAB9A 3882/4885
US-20080113993-A1 BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS HIF1A, HIF1AN, PDGFA MEN1 2707/4885NPC1 2098/4885RAB9A 3153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.