⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13044988 | 1.00 | — | — | |
| SCHEMBL15241782 | 0.82 | — | — | |
| SCHEMBL13208861 | 0.78 | — | — | |
| SCHEMBL14599212 | 0.78 | — | — | |
| SCHEMBL23707005 | 0.76 | — | — | |
| SCHEMBL9160497 | 0.76 | — | — | |
| SCHEMBL13044994 | 0.75 | METAP2 (0.40) | — | |
| SCHEMBL5848331 | 0.75 | METAP2 (0.50) | — | |
| SCHEMBL11533489 | 0.74 | — | — | |
| SCHEMBL17785087 | 0.72 | RNPEP (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403571-A1 | SYNERGISTIC COMBINATIONS OF METHIONINE DEPLETION AGENTS AND IMMUNE CHECKPOINT MODULATORS | ERYTECH PHARMA (FR) | 2021-12-30 | — | — | US | disclosed |
| EP-3146977-A1 | TFPI INHIBITORS AND METHODS OF USE | Baxalta GmbH (CH) | 2017-03-29 | — | — | EP | disclosed |
| US-20100292224-A1 | ISOTHIAZOLIDINE 1,1-DIOXIDE AND TETRAHYDRO-2H-1,2-THIAZINE 1,1-DIOXIDE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-18 | — | — | US | disclosed |