Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 11/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3028745 | 1.00 | HTT (0.48) | HTTHSD11B1NPY5RKCNH2ADRA1A | |
| SCHEMBL3026796 | 0.89 | HSD11B1 (0.49) | HSD11B1NPY5RSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3036715 | 0.88 | HSD11B1 (0.48) | HSD11B1NPY5RKCNH2SMN1; SMN2KDM4E | |
| SCHEMBL3032395 | 0.86 | NPY5R (0.51) | HSD11B1NPY5RKCNH2ADRA1AKDM4E | |
| SCHEMBL3021457 | 0.85 | HSD11B1 (0.51) | HSD11B1NPY5RKCNH2ADRA1ASMN1; SMN2 | |
| SCHEMBL13045544 | 0.85 | HSD11B1 (0.51) | HSD11B1NPY5RKCNH2ADRA1ASMN1; SMN2 | |
| SCHEMBL2998466 | 0.85 | HSD11B1 (0.51) | HSD11B1NPY5RKCNH2ADRA1ASMN1; SMN2 | |
| SCHEMBL3030982 | 0.84 | NPY5R (0.51) | HSD11B1NPY5RKCNH2KDM4EPOLB | |
| SCHEMBL3031924 | 0.83 | NPY5R (0.48) | HSD11B1NPY5RKCNH2ADRA1AKMT2A | |
| SCHEMBL3031925 | 0.83 | NPY5R (0.48) | HSD11B1NPY5RKCNH2ADRA1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286151-A1 | 1-OXA-3-Azaspiro[4,5]Decan--2-One Derivatives For The Treatment Of Eating Disorders | BENTLEY JONATHAN | 2010-11-11 | — | — | US | disclosed |
| US-20100286151-A1 | 1-OXA-3-Azaspiro[4,5]Decan--2-One Derivatives For The Treatment Of Eating Disorders | BENTLEY JONATHAN | 2010-11-11 | — | — | US | disclosed |
| US-20090042897-A1 | Chemical Compounds | GLAXO GROUP LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
| US-20090042897-A1 | Chemical Compounds | GLAXO GROUP LIMITED (GB) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042897-A1 | Chemical Compounds | NPY5R, NPY1R, NPY2R | HTT 1064/4885HSD11B1 1243/4885NPY5R 1/4885 |
| US-20100286151-A1 | 1-OXA-3-Azaspiro[4,5]Decan--2-One Derivatives For The Treatment Of Eating Disorders | NPY5R, NPY1R, NPY4R | HTT 1540/4885HSD11B1 202/4885NPY5R 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.