Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 2/20 | 0.44 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 4/20 | 0.42 |
| ▸ | MERTK | Q12866 | 4/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13048601 | 0.90 | MERTK (0.53) | ULK1ULK2IGF1RMERTKTYRO3 | |
| SCHEMBL13048739 | 0.88 | PTK2 (0.42) | ULK1ULK2IGF1RPDGFRAFLT3 | |
| SCHEMBL13048126 | 0.85 | ULK1 (0.53) | ULK1ULK2MERTKTYRO3FLT3 | |
| SCHEMBL13048722 | 0.82 | MERTK (0.47) | IGF1RMERTKTYRO3FLT3GAS6 | |
| SCHEMBL13048626 | 0.81 | SYK (0.45) | MERTKTYRO3FLT3SYKPIK3CD | |
| SCHEMBL13048598 | 0.81 | SYK (0.52) | MERTKFLT3AXLSYKPIK3CD | |
| SCHEMBL13048641 | 0.81 | SYK (0.45) | MERTKTYRO3FLT3GAS6AXL | |
| SCHEMBL13048648 | 0.80 | PIK3CD (0.43) | PDGFRACCNE1CDK2TYRO3SYK | |
| SCHEMBL13048627 | 0.80 | PIK3CD (0.41) | CDK2TYRO3SYKPIK3CDPIK3CA | |
| SCHEMBL13048827 | 0.80 | SYK (0.43) | IGF1RMERTKCDK2TYRO3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298557-A1 | PYRAZOLOPYRIMIDINE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-11-25 | — | — | US | disclosed |
| US-20100298557-A1 | PYRAZOLOPYRIMIDINE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298557-A1 | PYRAZOLOPYRIMIDINE COMPOUND | SYK, LCK, FYN | ULK1 851/4885ULK2 434/4885IGF1R 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.