Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | PRKACG | P22612 | 1/20 | 0.55 |
| ▸ | PRKACB | P22694 | 1/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 8/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.54 |
| ▸ | NFATC1 | O95644 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 5/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12723010 | 0.91 | ABL1 (0.55) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL13051120 | 0.87 | ABL1 (0.58) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL30847342 | 0.86 | ABL1 (0.57) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL27109944 | 0.86 | ABL1 (0.57) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL2542944 | 0.86 | CCNB2 (0.67) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL13051126 | 0.85 | DYRK1B (0.60) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL13051121 | 0.84 | CDK2 (0.56) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL13051124 | 0.84 | EGFR (0.59) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL13239597 | 0.83 | RET (0.76) | PRKACACDK2GSK3BCDK1CCNB1 | |
| SCHEMBL13051122 | 0.83 | DYRK1B (0.52) | ABL1EGFRBCRSRCPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| WO-2009092431-A1 | 4-(PYRROLO[2,3-C]PYRIDINE-3-YL)-PYRIMIDINE-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | ABL1 267/4885EGFR 2251/4885BCR 3369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.