Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.64 |
| ▸ | GSK3B | P49841 | 5/20 | 0.64 |
| ▸ | NFATC1 | O95644 | 4/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 3/20 | 0.49 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.48 |
| ▸ | TDO2 | P48775 | 2/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13051111 | 0.91 | DYRK1A (0.62) | DYRK1AGSK3BNFATC1PDPK1CDK2 | |
| SCHEMBL13051138 | 0.88 | DYRK1A (0.65) | DYRK1AGSK3BNFATC1PDPK1CDK2 | |
| SCHEMBL13051143 | 0.87 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1PDPK1CDK2 | |
| SCHEMBL13051145 | 0.87 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1PDPK1CDK2 | |
| SCHEMBL3657990 | 0.84 | DYRK1A (0.60) | DYRK1AGSK3BNFATC1CDK2CDK9 | |
| SCHEMBL13051144 | 0.81 | DYRK1A (0.60) | DYRK1AGSK3BNFATC1PDPK1CDK2 | |
| SCHEMBL13051147 | 0.81 | DYRK1A (0.60) | DYRK1AGSK3BNFATC1PDPK1CDK2 | |
| SCHEMBL1586849 | 0.81 | ADORA2A (0.51) | DYRK1AGSK3BNFATC1PDPK1CDK2 | |
| SCHEMBL13051140 | 0.80 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1PDPK1CDK2 | |
| SCHEMBL17179566 | 0.79 | DYRK1A (1.00) | DYRK1AGSK3BNFATC1PDPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| WO-2009092431-A1 | 4-(PYRROLO[2,3-C]PYRIDINE-3-YL)-PYRIMIDINE-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | DYRK1A 2428/4885GSK3B 1642/4885NFATC1 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.